As we move towards "HIV undetectable" take note of the message in this abstract!

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Estimating the range of potential epidemiological impact of pre-exposure prophylaxis: run-away success or run-away failure?.
Cremin, Íde; Hallett, Timothy B.
Supplemental Author Material
Published Ahead-of-Print
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Abstract
Objective: To investigate the influence of potential interactions between key aspects of a pre-exposure prophylaxis (PrEP) intervention on projections of epidemiological impact and cost-effectiveness.
Methods: A mathematical model representing the HIV epidemic and intervention context in Nyanza province in Kenya was developed. We consider a scenario whereby a fixed annual budget is allocated to a PrEP intervention. A standard projection of impact is generated, assuming that the unit cost of PrEP, adherence to PrEP and the ability of the programme to direct PrEP to those at high risk, all stay constant. The influence of dynamic assumptions and possible interactions between PrEP intervention assumptions is then assessed in comparison.
Results: The cumulative impact of a PrEP intervention could be increased approximately two-fold, relative to the standard projection, if positive interactions (between coverage and cost, coverage and adherence, prioritization and time) are assumed, whereas negative interactions between these factors could almost entirely negate the preventive benefit of the PrEP intervention. The corresponding estimates of cost per infection averted span a wide range from $2060 to $36 360.
Conclusions: Multiple potentially interacting factors will determine the impact of PrEP. Model forecasts should reflect that uncertainty and programmes should focus on these factors and measure them, to maximize the impact of programmes.
Copyright (C) 2015 Wolters Kluwer Health, Inc.

Comments

  1. Unknown5 September 2015 at 13:45

    Dr. ARIBA but have heard of his excellent work on people's life. We contacted Dr. Ariba and he started his work on her life and right now my wife is cured. she was diagnosed with Herpes And HIV and after taking Dr. Ariba Herbal medicine she was cured. You can reach him draribaspelltemple@gmail.com OR dr.aribaspelltemple@outlook.com

    Website: great-drariba.webs.com

    ReplyDelete
    Replies
    1. Unknown5 September 2015 at 16:05

      I have not met Dr. ARIBA but have heard of his excellent work on people's life. We contacted Dr. Ariba and he started his work on her life and right now my wife is cured. she was diagnosed with Herpes And HIV and after taking Dr. Ariba Herbal medicine she was cured. You can reach him draribaspelltemple@gmail.com OR dr.aribaspelltemple@outlook.com

      Website: great-drariba.webs.com

      Delete
    2. Anonymous15 November 2015 at 15:30

      I have not met Dr. ARIBA but have heard of his excellent work on people's life. We contacted Dr. Ariba and he started his work on HIS life and right now my Husband is cured. He was diagnosed with Herpes And HIV and after taking Dr. Ariba Herbal medicine he was cured. You can reach him draribaspelltemple@gmail.com OR dr.aribaspelltemple@outlook.com

      Delete
  2. Unknown5 September 2015 at 15:29

    I’m Zaldy Arzije, I’m from Virginia. I was tested HIV Positive when I started having some symptoms of HIV, I came across Dr. Oraede web page, so I contacted him via his email address; I explained things to him and he assured me that he’s going to send me the medicine; he prepared the medicine and send it to me through UPS Courier Service. When I received the medicine I took it as prescribed by him. He asked me to go for check-up after finishing the medicine, I was tested Negative, I was cured me from HIV. If you have any Virus or Disease like, HIV, CANCER, HEPATITIS B, A, C, DIABETIS e.t.c. contact him so that you will be cured by him okay.. Contact him via his email on dr.oraedeherbalhome@yahoo.com dr.oraedespellhome@hotmail.com www.dr-oraede.webs.com +2349038604218

    ReplyDelete
  3. Anonymous15 November 2015 at 15:30

    I have not met Dr. ARIBA but have heard of his excellent work on people's life. We contacted Dr. Ariba and he started his work on HIS life and right now my Husband is cured. He was diagnosed with Herpes And HIV and after taking Dr. Ariba Herbal medicine he was cured. You can reach him draribaspelltemple@gmail.com OR dr.aribaspelltemple@outlook.com

    ReplyDelete
  4. HIV Must Not Win15 November 2015 at 16:02

    Great news! You should all avail yourselves to organizations like CDC to make a peer reviewed analysis to your wonderful news! Thanks

    ReplyDelete

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